One Year With OneSkin OS-01 - Review, Questions and Where to Start

we have updated our oneskin OS-o1 Review

Curious to know if OneSkin OS-01 actually works?

At Longevity Blog, looking younger is about far more than vanity. How ‘young’ you look is an asset to be protected, an investment in your longevity, particularly in developing and maintaining a longevity mindset.

But as we have previously explored, keeping your skin young and healthy extends into actual, tangible longevity benefits much beyond aesthetics and how young you ‘feel’. By switching on the repair mechanisms of your skin, you are reducing systemic inflammation across the body. In doing so, you’re slowing down ‘inflammaging’, one of the key reasons you get biologically older in the first place

In our interview with OneSkin CEO and Co-Founder Dr. Carolina Reis, we heard about the destructive role of senescent cells in the skin. These aged cells send off inflammatory signals to the surrounding tissue, which extend their impact throughout the body.

But, by looking after the healthspan of the skin - “skinspan” as OneSkin refers to is - we can halt or even reverse this process.

“Once you have senescent cells, there is a cascade of inflammatory signals leading to events such as collagen breakdown, which in turn will lead to a series of further dysfunctions in the skin.

These results in breaks in the skin barrier, and eventually, the signs of aging that we experience growing older, which are loss of firmness, wrinkles, dark spots, and so on.

If we're able to partially block the senescent cell feed forward loop, this allows the young and healthy cells to continue to proliferate, keeping up with healthy collagen and repairing your skin barrier, essentially reversing aging.” (Dr. Carolina Reis in our interview with her from February 2022)

But does oneskin actually work?

A classy, sustainable and innovative product. OneSkin OS-01 FACE.

It’s one thing to claim you can reverse skin aging, another to suggest you can halt or reverse cellular senescence in the skin.

It is another matter altogether to prove it. To know - “Does OneSkin OS-01 actually work?”

At Longevity Blog, our job is to put such claims to the test. And we did this, in a groundbreaking self-experiment that we published in August 2022 after our Founder Nick tested their product on his face for six months.

The results were impressive. With a reduction in Nick’s apparent skin age (as measured by a Visia scanner) of 7 years. (See the Before and After review here)

ONeSKin OS-01 - ONe year Later

In this brief follow-up, we wanted to share Nick’s further experience with OneSkin OS-01 after 12 months of using this product.

It’s natural to wonder, what happens after longer term use of OneSkin? Or was the testing a fluke? Could another factor have been in play?

Over the course of the 12 month period, Nick did not make any major changes to his skincare routine. He maintained regular sunscreen use and daily cleaning with a squalene cleanser. He applied a generous amount of OneSkin OS-01 FACE each evening, and watched the results come in.

As Nick is now executing a follow-up self-experiment with IPL Laser Therapy (be sure to subscribe to get notified when we drop this exciting new video project!), it was time to gather some additional Visa scanner data.

What he found might surprise you….


PARTNER Discount Code!

A part of our mission is to make your longevity budget stretch further.

Through our collaboration with OneSkin, we have a negotiated a 15% off coupon code for our readers.

Use the code longevityblog at checkout to save!

Note: You must use the above link for the discount code to be applied to your order.


OneSkin OS-01 FACE, after 12 months of continual use at once per day, significantly improves skin texture.

OS-01 FACE Smooths Skin Texture Dramatically

Texture as measured by the Visia Scanner is primarily an analysis of skin smoothness. Texture measures skin color and smoothness by identifying gradations in color from the surrounding skin tone, as well as peaks (yellow) and valleys (blue) on the skin surface that indicate variations in the surface texture.

While Nick’s forehead was not sampled in the before image, his cheeks were in both the before and after. We can see a dramatic decrease in the peaks and valleys from left to right.

Anecdotally, Nick’s skin ‘feeling smoother’ was on of the most notable benefits of using OneSkin.


OneSkin OS-01 FACE, after on year of daily use, appears to reverse Nick’s wrinkles.

ONESKIN reverses wrinkles


While we saw a significant decrease in wrinkles after six months, those changes were only just beginning. After 12 months, we can see the Visia scanner barely detects wrinkles on Nick’s face.

“Wrinkles” are furrows, folds or creases in the skin. These are known to increase in occurrence as a result of sun exposure, and are associated with decreasing skin elasticity.

“Once you have senescence cells, there is a cascade of inflammatory signals leading to events such as collagen breakdown, which in turn will lead to a series of further dysfunctions in the skin.

These results in breaks in the skin barrier, and eventually, the signs of aging that we experience growing older, which are loss of firmness, wrinkles, dark spots” -Dr Carolina Reis, OneSkin CEO- (read the interview)


OneSkin OS-01 FACE using it for one year seemingly halts the accumulation of new UV damage.


OS-01 Peptide holds UV damage stable

While we didn’t see any big changes in Nick’s UV damage levels over the 12 months, this means more than you might think.

UV damage is accumulating due to sun exposure over the course of your life. As a triathlete, Nick is outside often and gets plenty of sun exposure. Australia, where Nick lives, is also known for very high UV levels and high incidence of skin cancers.

You can learn about technologies for detecting skin cancers early in our interview with MoleMap.

The analytics on the Visia Scanner showed a small, but meaningful decrease in ‘feature count’ - otherwise tracking the total number of UV spots underneath his skin.

With this small decrease and UV damage overall holding stable, even with Nick getting chronologically ‘older’ - it does look like OneSkin OS-01 is helping out in this category too, although less dramatically.


OneSkin OS-01 FACE, used for 12 months with no other changes, significantly improves spotting (skin lesions, pigmentation).

ONESKIN OS-01 FACE reduces spotting

“Spots” as detected by the Visia Scanner are typically brown or red skin lesions including freckles, acne scars, hyper-pigmentation and vascular lesions.

Spots are distinguishable by their distinct color and contrast from the background skin tone. Spots vary in size and generally have a circular shape.

After one year with OneSkin, Nick’s spotting dropped by an impressive 40%!


ONESKIN after one year - We’ll keep Using it!

Our verdict continues to be that OneSkin OS-01 not only works, but is an essential part of your longevity strategy for your skinspan.

In world awash in ‘beauty’ products and ‘skincare’ brands, we are proud to be collaborating with a longevity technology company like OneSkin who are breaking the mould and targeting skin aging at its source.

However, these results really only apply to one person - that’s our Founder Nick. If you want to know if OneSkin OS-01 will work for you - there’s only one way to find out!

Run your own self-experiment! We provide some good tips on how to do just that in our previous blog post here.

If you decide to give OneSkin a try, be sure to use our exclusive discount code to save 15% and extend your longevity budget just a bit further.

Enter ‘LONGEVITYBLOG’ at checkout. Note that you must use our unique link here to have this code applied to your order.

If you do self-experiment, we’d love to hear from you! Please share your results with us and who knows, you might just end up on Longevity Blog yourself!


The First Longevity Blog Video Project is Here - IPL Laser Therapy


FDA & TGA DISCLAIMER

This information is intended for educational purposes only and is not meant to substitute for medical care or to prescribe treatment for any specific health condition. These blog posts are not intended to diagnose, treat, cure or prevent any disease, and only may become actionable through consultation with a medical professional.

Longevity Blog Team

Contributions from the Longevity Blog team, which are informational and strategic in nature. Learn more about our mission!

http://nickengerer.org
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